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This immune activation occurs through multiple pathways including modulation of interleukin signaling and regulation of immune cell differentiation

Reduced Oxidative Stress: As an antioxidant, Epitalon decreases reactive oxygen species and boosts antioxidant enzymes, protecting cells from oxidative damage, a major contributor to aging and age-related diseases

Ketorolac (Acular) Mechanism: Inhibits cyclooxygenase (COX-1 and COX-2), reducing prostaglandin production and relieving pain and inflammation

We next repeated this experimental paradigm in Gipr hypo-KO and Gipr hypo-GFP mice, combining the initiation of HFD with a combination of LIRA (or VEH) alone or LIRA (or VEH) plus GIPR antagonist peptide (GIPR-antag)