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Sin embargo, tras los estudios de fase 2, se observaron efectos secundarios gastrointestinales importantes, una tolerancia deficiente y complicaciones con la formulacin para administracin sostenida

To limit such effects at the high doses and exposure levels associated with effective PCSK9 neutralisation, the potency of the GLP-1 peptide component in the fusion was optimised

And, avoid eating too close to bedtime