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I argued last year that the GLP1a drug semaglutide was disease-modifying in patients with established heart disease and obesity because the SELECT trial showed reductions in hard clinical endpoints

Budirahardja, Y., Tan, P

The recombinant protein converted fibrinogen into fibrin clot in vitro and was able to shorten bleeding time and whole blood coagulation time in vivo

While the Australian agency acknowledged that Ozempic was being prescribed "off-label," they noted the Australian government "does not have the power to regulate the clinical decisions of health professionals and is unable to prevent doctors from using their clinical judgment to prescribe Ozempic for other health conditions." After a few months, Roy said, Trish switched to Saxenda another injectable to lose even more weight