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DHODH Dihydroorotate dehydrogenase (DHODH) is a flavin-dependent mitochondrial enzyme that catalyzes the fourth step in the de novo synthesis of pyrimidine nucleotides and is a key enzyme in pyrimidine synthesis
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A minimal mathematical model is to assume the oxidation of GSH to GSSG (but not the reduction of GSSG to GSH) is proportional to plasma glucose, that is, to ROS
Furthermore, those concerned about Can glutathione cause liver damage
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