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The reaction begins when methionine synthase takes a methyl group from active folate (5-methyltetrahydrofolate) and uses methylcobalamin to transfer that methyl group to a naturally occurring amino acid called homocysteine

Notably, these effective concentrations were 16,000-80,000,000 times lower than concentrations of melatonin required for comparable effects, suggesting highly potent regulatory mechanisms rather than simple antioxidant activity

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The Suppressor of Killer of prune, a unique glutathione S-transferase [PMID: 16944302] Laboratory literature summary: The Suppressor of Killer of prune, a unique glutathione S-transferase