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Methylmalonic aciduria and homocystinuria (MMACHC) is a cytosolic chaperone for cobalamin (vitamin B12) and can be converted into the active cofactor methylcobalamin, which participates in methionine synthesis ( SAM functions as an essential precursor in the biosynthesis of polyamines, including spermine and spermidine (Figure 2)
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Available at: Accessed November 7, 2024
There are 19 clinical trials underway across the TRIUMPH, TRANSCEND, and SYNERGY programs
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