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This includes the upregulation of ferritin heavy and light chain, ferroportin, transferrin receptor and heme oxygenase-1 (HO-1), alongside increased production of NADPH, GSH and CoQ10 (coenzyme Q10) which counter lipid peroxidation and suppress ferroptosis (66,67)
Recent investigations have focused more on combination therapies, particularly pairing glutathione with its precursors (l-cystine, cysteine peptides) or other antioxidants (vitamin C, alpha-lipoic acid, zinc), reflecting the understanding that synergistic effects may enhance skin-lightening outcomes
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