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To adjust for potential confounding, we used inverse probability of treatment weighting (IPTW) based on propensity scores, a method that allows balancing without losing generalisability [17]
In a study conducted in obese male patients all exenatide responders, defined as those who consumed lower food calories by exenatide administration compared to placebo, exhibited significantly higher hypothalamic connectivity measured by food cue-paired fMRI compared with placebo injection [41]
We also acknowledge that the study has some limitations
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