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Importantly, redox imbalance acts as the molecular bridge through which IR and HA reinforce each other while maintaining a chronic inflammatory state ( 2.4 Redox-endocrine vicious cycle in PCOS The pathophysiology of PCOS is underlined by a self-reinforcing redox-endocrine loop that integrates OS, hormonal dysregulation, and metabolic dysfunction into a persistent pathological circuit

So because B12 is water soluble, there is no toxicity

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