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An invasive approach includes delivery of medication directly to the brain through injection/surgical implants or disruption of the tight endothelial junction of the BBB to facilitate drug penetration
10.1073/pnas.0914076107 98 ValerioA.BassoD.BrigatoL.CeolottoG.BaldoG.TiengoA.et al (1999)
Poor hygiene or reused needles can cause infection, and an injection placed badly can rarely irritate a nerve
Results of this integrated analysis suggest that the triple combination of GLP-1RA, SGLT2i, and finerenone provides stronger cardiorenal protective benefits than either conventional therapy or each alone
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