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Another study found that shRNA suppression of MIF in murine breast cancer cell lines inhibited primary tumor expansion and decreased lung micro-metastases in immunocompetent Balb/c mice, but not in immunodeficient SCID mice

(vii) absence of a better explaination by other diseases

This discrepancy between formal trial data and patient-reported experiences may reflect several factors: cold sensitivity might not have been specifically monitored in trials, it may be attributed to weight loss rather than the medication, or it might affect only a subset of patients