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3 Safety & Tolerability Under the Microscope Injection-site reactions were notable: 12% with CagriSema 17% with cagrilintide alone 2.6% with semaglutide alone While overall discontinuation remained low (~1%), tolerability will be a key differentiator versus Lillys portfolio

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This mechanism is central to how GLP-1 receptor agonistsmedications that mimic natural GLP-1work to regulate blood glucose levels and promote weight loss

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