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PMC 5998102
Oxidative damage markers such as malondialdehyde (MDA) and 8-oxo-deoxyguanosine (8-oxo-dG) indicate damage to lipids and DNA respectively [138]
Patients should inform their healthcare provider about all medications and supplements, especially if they have kidney disease, as metformin requires dose adjustment when kidney function declines
Therefore, clinicians must consider study design, population characteristics, and possible confounding factors
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