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No dose adjustment is required for patients with renal impairment (including end-stage renal disease) or hepatic impairment, as pharmacokinetic differences are not clinically meaningful
PMID:39777204
Elevated androgens promote sebaceous gland hypertrophy and increased sebum production, creating an environment conducive to Cutibacterium acnes proliferation and inflammatory acne lesions
Keep in mind, though, that this is based on results from rodent studies, so its still unclear whether these medications contribute to thyroid tumors in humans
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