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One of the most robust and widely documented effects is the induction of vitellogenin in male fish, a thoroughly validated and reproducible biomarker of estrogenic exposure
Circulation 115:12851295
These results support a useful selectivity window for NNMT research, but they were obtained with a limited panel of related enzymes and do not rule out every possible off-target interaction
Two of the most promising areas are antibody-based treatments and cell-based therapies
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