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A proof-of-concept trial in Nature Medicine found that supplementation with a pasteurized form of Akkermansia in overweight and obese volunteers was safe, well tolerated, and associated with improvements in several metabolic markers, including insulin sensitivity and blood lipids (Depommier et al., 2019)

It mimics the effects of the hormone glucagon-like peptide-1 (GLP-1), which stimulates the release of insulin to control blood sugar

Patients with a history of medullary thyroid carcinoma (MTC) or multiple endocrine neoplasia syndrome type 2 (MEN 2) are at a higher risk of developing thyroid C-cell tumors