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The critical role of this multi-faceted lactate shuttle is underscored by its validation across multiple tumor models (e.g., breast, prostate, osteosarcoma), where elevated MCT4 expression in CAFs is closely associated with enhanced tumor aggressiveness
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There was no effect on fertility in male or female rats following administration of tesamorelin acetate at doses up to 0.6 mg/kg (approximately equal to clinical exposure) for 28 days in males or 14 days in females
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