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Packer M, Zile MR, Kramer CM, Baum SJ, Litwin SE, Menon V, et al
Prolonged lack of sleep increases inflammation levels and causes blood sugar imbalances, which may eventually lead to a drop in glutathione
This is true of virtually every longevity intervention currently in use, including metformin
In the presence of oxidative stress, Nrf2 triggers the expression of HO-1, shieldings cells from oxidative stress thorough heme breakdown
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