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Packer 2025 in NEJM (PMID 39555826) reported on heart failure with preserved ejection fraction (SUMMIT), with tirzepatide producing improvements in patient-reported symptom burden and quality-of-life scores
Increased serum creatinine, renal impairment, worsened chronic renal failure, and acute renal failure, sometimes requiring hemodialysis and kidney transplantation have been reported
& Metallo, C
Messer are skeptical that the compounds could have the same effects as the synthetic versions
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