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11,12 For instance, the success of exenatide has not only spurred the development of potent GLP-1 analogs such as liraglutide and semaglutide but also unveiled the vast potential of GLP-1RAs in treating various systemic diseases

Modern lifestyle habits, unhealthy eating routines, stress, and lack of physical activity can affect metabolism and body fitness

In the only reported trial to date involving people with AUD who actively wished to reduce or cease drinking, a once-weekly GLP-1 agonist called exenatide did not result, in the overall group, in a reduction of the number of heavy drinking days, but the drug did enable those with AUD and obesity to do so

Prescribers and patients should hold that gap clearly in mind