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46 However, the effects may vary at different stages of the disease, as evidenced by the study showing that the reduction was most pronounced in the early stages but less so in more advanced stages with behavioral symptoms

UK patients should understand that: Available evidence is largely from Phase 2 studies with relatively short follow-up periods Long-term cardiovascular outcome data are not yet available for either agent Phase 3 trials are ongoing, and results will inform future regulatory submissions to the MHRA UK patients interested in accessing these treatments through clinical trials may wish to consult the NIHR 'Be Part of Research' portal (bepartofresearch.nihr.ac.uk) or ClinicalTrials.gov for current recruitment opportunities

Relating to the presence of incretin receptors on endothelial cells, TZP can also reduce blood pressure (BP) (58)