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This shared mechanism supports their potential as sustainable interventions for heavy metal toxicity in animal production (6, 7)

Note: Eli Lilly terminated a Phase IIb trial combining bimagrumab with tirzepatide (Zepbound) for "strategic business reasons," though a separate non-diabetic obesity trial remains ongoing

For example, mice fed a high-fat diet for 21 days have both lipid and protein compositional changes in cellular plasma membranes that result in an impaired capacity for oxidative phosphorylation, increased reactive oxygen species (ROS) production, hepatosteatosis and insulin resistance (Shama et al., 2023)

Furthermore, the review emphasize the need for further development of nanotechnology-based antioxidant treatments, including innovation in nanoparticle design, stability of nanoparticles, and targeting mechanisms