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(68), which reported that sweet taste receptor antagonism with lactisole reduced GLP-1 and PYY secretion but had no effect on CCK release, highlighting pathway-specific effects

The Takeaway: Rapid Weight Loss and Facial Appearance Rapid weight loss, whether through diet and exercise, bariatric surgery, or medications, can have beneficial effects but also lead to noticeable changes in facial appearance

In women, excess body weight can disrupt the delicate hormonal balance required for regular ovulation

Tirzepatide promotes a higher level of weight loss but also typically results in slightly more severe side effects