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PMID 12729762

and decreased the expression of caspase-3, inhibited apoptosis, and ultimately attenuated cisplatin-induced hair cell loss in the HEI-OC1 cell line ( Pomegranate extract (PE) is rich in polyphenols and exhibits strong antioxidant activity (Sahin et al., 2025)

Although the direct cytotoxic effects of high cellular GSSG levels have been documented in a variety of cell types 33,34,35,36 , our cell culture studies with hepatocytes revealed that increased GSSG accumulation, despite being non-toxic per se, could sensitize hepatocytes to TNF-induced killing, suggesting that GSSG and TNF can synergistically induce hepatocyte death and that GSSG-triggered sensitization to TNF hepatotoxicity represents a clinically relevant process that may account for disease progression in NAFLD