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10 In mesenchymal stem cell models, the GLP-1RPKA-catenin axis has been shown to modulate the balance between adipogenesis and osteogenesis, indicating a direct impact on cell differentiation and tissue remodeling
Meet our doctors Last reviewed: 26 Feb 2026 Sources An update on recurrent acute pancreatitis: data from five European countries, PubMed [accessed 25 February 2026] Constipation, NHS [accessed 25 February 2026] GLP-1 Receptor Agonists and Related Mental Health Issues
Although some studies have shown an increased risk for thyroid cancer and pancreatitis in human patients, these studies are difficult to interpret due to reporting bias, lack of controlling for other patient medical histories and comorbidities, the fact that obese people are already highly at risk for specific forms of cancer and may already have primordial tumours present when beginning medication and are likely to be taking other medication apart from GLP1R agonists as well [55]
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