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In head-to-head trials against semaglutide, the most potent available GLP-1 receptor agonist, tirzepatide demonstrated meaningfully greater improvements in both glycemic control and weight reduction
GLP-1-mediated targeting of inflammation corrects obesogenic memory in male mice
Por otro lado, la unin del GLP-1 con su receptor en la CBP tendra un efecto directo sobre la secrecin de insulina, potenciando las dos fases de secrecin de insulina y estimulando la transcripcin del gen y la traduccin del ARNm, incrementando as la biosntesis de proinsulina 25,26
Am Surg 87(8):12871291
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