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Conclusions A simple and sensitive LCMS/MS method has been developed and fully validated for the quantification of tirzepatide in rat plasma in accordance with the FDA bioanalytical method validation guidance

The affinity of PF-06882961 (K i = 80 nM) measured using this new radioligand was 4.5-fold more potent and more consistent with its cAMP potency, whereas the clinical peptides had similar affinities using both radioligands (Table S6)

Initially, the neuroprotection of GLP-1RAs was tested in in vivo models of diabetes