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While weight cycling (repeated loss and regain) has some negative health associations, these are primarily correlation, not proven causation

Ooi YP, Weng SJ, Jang LY, Low L, Seah J, Teo S, et al

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Cagrilintide combined with semaglutide (CagriSema) for treatment of type 2 diabetes In a recent small phase 2 trial (n=92), 3 groups of patients with type 2 diabetes were randomized to receive cagrilintide co-administered with semaglutide (the authors called this combination CagriSema), cagrilintide or semaglutide, both in doses escalated to 2.4 mg once weekly (table 1) [10]