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In preclinical studies of cancer cell lines and tumor xenografts, auranofin exhibits remarkable sensitivity across various forms of drug-resistant cancer cells, including ovarian cancer with a cisplatin-resistant phenotype [235]
Cryo-EM structural studies published in 2024 confirmed how a single peptide can adopt the conformational geometry required to activate all three receptor types, with each binding interaction producing measurable cAMP-mediated intracellular responses [9]
Women using oral contraceptives should use backup contraception for 4 weeks after Zepbound initiation and after each dose escalation, as delayed gastric emptying may reduce contraceptive effectiveness
