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This balancing act was attempted by Novo Nordisk, when they developed a triple agonist , compound 16, which in mice was able to reduce body weight by an average of around 30%, fat mass by around 55% and lean mass by around 10% after 27 days [33]
GLP-1s can become less effective over time
In contrast, whether the unstable gut-derived GLP-1 directly acts on pancreatic -cells remains controversial [58]
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