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Diagnostic work-up and management of patients with isolated methylmalonic acidurias in European metabolic centres
Although vitamin B 12 deficiency is known to damage the myelin sheath covering cranial, spinal, and peripheral nerves, the biochemical processes leading to neurologic damage in vitamin B 12 deficiency are not yet fully understood (22)
135 Cytokines such as TGF- and IL-6 further enforce these adaptations by reshaping the immune and metabolic landscape
The immune system comprises different organs, cells, and proteins that fight infection (microbes)
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