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A recent review of the biological rationale and evidence for considering pregabalin for the management of symptoms of CIPN concluded that pregabalin is not likely to prevent CIPN, but shows promise for treatment of established CIPN (Davis 2022)

Nrf2 not only increases the enzyme levels of both the oxidative and non-oxidative arms, but it also facilitates the utilization of ribose 5-phosphate for the purine nucleotide synthesis (Mitsuishi et al., 2012), which appears to maintain the ribose 5-phosphate concentration at a low level and efficiently divert glucose flux into purine nucleotide synthesis through both arms of the pentose phosphate pathway

Availability TB-500 and BPC-157 are available through the official store at Core Peptides in either 10 mg or 20 mg vials, with discounts for bulk quantities

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