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In this review, detailed information on drug-induced kidney injury mechanisms and available in vitro models to predict this with relevant translational biomarkers will be discussed, with an emphasis on novel developments in the field of microphysiological systems that meet the requirements of the 3Rs (replacement, reduction, refinement) of animal experiments for drug safety screenings

After the salt is selected, the salt concentration requires optimization

Older individuals: Aging leads to decreased gastric acid production, reducing B-12 release from bound proteins

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