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Patient-reported outcomes with hypoglossal nerve stimulation for treatment of obstructive sleep apnea: a systematic review and meta-analysis
Researchers studying receptor desensitization also use paired GHRH/GHS protocols to compare downregulation kinetics against single-agent controls, since repeated stimulation of the GHRH receptor alone can blunt responsiveness over time in ways that combined signaling may partially offset
They can be useful when an approved drug cannot meet a particular patients needs, but they also carry additional risks
The FDA requires stopping GLP-1 medications at least two months before attempting pregnancy due to animal studies showing potential fetal harm
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