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In line with UK Summary of Product Characteristics (SmPC) guidance for approved agents in this class: Retatrutide should not be used during pregnancy
Conversely KEAP1-dependent repression of NRF2 is required for intestinal stem cells (ISCs) from Drosophila to proliferate, although complete loss of NRF2 results in ROS accumulation and intestinal degeneration ( in vivo (Zhang et al., 2014)
These sections include discussion of the currently published trials that support the safety and efficacy of each drug
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