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Not responding to the drugs, Kim noted, means not losing weight
Data from the ORION study, presented at the Obesity Medicine Associations 2026 annual conference, showed that oral semaglutide 25 mg was associated with significantly greater mean weight loss than orforglipron in a population-adjusted indirect treatment comparison
In addition, NLRP3 knockdown also decreased PFKFB3 expression, indicating that NLRP3 inflammasome activation contributed to PFKFB3-driven glycolysis
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