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The key preclinical data urgently needed before clinical trials can commence include: (i) efficacy and immune-profiling data derived strictly from clinically relevant orthotopic and spontaneous pulmonary metastasis models, rather than simple ectopic subcutaneous models
Role of Proton-Coupled monocarboxylate transporters in cancer: from metabolic crosstalk to therapeutic potential
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Restoring NAD+ levels in animal models has reversed multiple aging biomarkers
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