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The presence of pre-transplant DSAs or the development of de novo DSAs (dnDSAs) is linked to ABMR and graft failure (28)

Natural killer cytotoxicity - the ability of NK cells to kill target cells such as those infected by viruses - also increased by more than two-fold compared to placebo

In Phase 2 research, this pharmacological profile translated into the largest average weight reductions ever reported for a once-weekly peptide, catalyzing widespread interest among endocrinologists, obesity researchers, and metabolic-disease scientists

Titration context: study schedules include eligibility rules and monitoring plans