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While the majority of side effects so far reported to the MHRA for tirzepatide and semaglutide are non-serious 22 , there are growing warnings about serious conditions, such as acute pancreatitis, associated with GLP-1 use, although studies currently remain inconclusive 25

Epidemiological studies have demonstrated a correlation between hyperglycemia and the severity of cardiovascular dysfunction and mortality in patients with DM [3, 4]

The rising obesity rates are closely linked to an increase in obesity-related comorbidities, including type 2 diabetes, hypertension, cardiovascular diseases, and certain cancers

That's because there arent any large-scale human studies that have confirmed the safety of GLP-1s in pregnant women