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Conversely, empty capsids produced from the cell culture infected at 34C (empty capsid B, Scheme 1) co-eluted with infectious CVA21 virions and required either further optimization of GSH chromatography parameters or development of a polishing chromatography step to clear residual empty capsids
The second option is to have vitamin B12 injections
Maintenance Dose: Once B12 levels are normalized, a maintenance dose of 1,000 mcg monthly or every few months may be recommended
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