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Break periods between cycles Between AOD-9604 cycles, a break period allows receptor sensitivity to restore and prevents potential adaptation that could reduce effectiveness in future cycles

Controlled study of induced granulomas treated with NAC showed 2-fold increase in GSH, 3-fold increase in Interferon-, 2- and 3-fold reduction in tumor necrosis factor- (TNF-) at 8 and 15 days, reduced reactive oxygen ions and reduced necrosis as compared to controls (68)