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l-dopa) can cross the BBB and reach brain tissue via l-type amino acid transporter-1 (LAT-1), the member of solute carrier (SLC) family present at the brain endothelium and diverse brain cells [6]
Eur J Biochem 267:49044911 Krahenbuhl S, Krahenbuhl-Glauser S, Stucki J, Gehr P, Reichen J (1992) Stereological and functional analysis of liver mitochondria from rats with secondary biliary cirrhosis: impaired mitochondrial metabolism and increased mitochondrial content per hepatocyte
[PubMed: 9849822] Svensson J, et al
GLP-1s may also worsen certain gastrointestinal conditions, such as severe gastroparesis, because they slow stomach emptying
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