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20 See Table 3: Appendix A: Detailed tables

Furthermore, since both glucagon and GLP-1 receptors are expressed in the endocrine pancreas, GLP-1R agonists such as semaglutide may also indirectly ameliorate inflammatory injury by regulating various metabolic parameters, including glucose-dependent insulinotropic peptide (GIP), glucagon, insulin, glucose levels, and circulating free fatty acids 16,17

As the dose increases, the appetite-suppressing effects typically become stronger

Cardiovascular biomarker correlation studies, particularly in the SURPASS clinical research programme, have documented favourable shifts in lipid profiles, inflammatory markers, and natriuretic peptide levels