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Melatonin not only regulates the bodys biorhythms and sleep patterns but may help reduce the oxidative damage that occurs with aging, especially in the central nervous system and in diseases such as Alzheimers disease (cognitive disorder.) When to Supplement In diseased or older animals, excess oxidation can occur which means the bodys normal antioxidant abilities are overwhelmed

When followed up from initiation of metformin, 10% of individuals with the AA genotype will be vitamin B 12 deficient by 11 years compared with 21 years for the GG genotype group