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1 Based on the treatment policy estimand (primary statistical analysis): treatment effect regardless of treatment adherence 2 Based on the hypothetical strategy estimand (supplementary statistical analysis): treatment effect excluding the occurrence of intercurrent events Contact Information for Hengrui Pharma DGA Group [email protected] Contact Information for Kailera Maura Gavaghan Vice President, Corporate Communications and Investor Relations [email protected]

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Janice Jin Hwang, chief of the division of endocrinology and metabolism at the University of North Carolina at Chapel Hill, explains that there are these networks of brain regions that have been very well characterized, mainly in addiction literature, that control our desire and motivation for food but also for addicting things. One reason food lights up reward pathways is that its essential for survival, says Lorenzo Leggio, an addiction researcher at the National Institute on Alcohol Abuse and Alcoholism and the National Institute on Drug Abuse

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