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In the head-to-head SURMOUNT-5 trial (NEJM, 2025), tirzepatide produced 20.2% body weight loss vs 13.7% for semaglutide at 72 weeks, with similar side-effect profiles
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This is significant because it may allow an additional reduction in liver fat, potentially helping to reduce liver inflammation and fibrosis, two causes of obesity-related complications
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If nausea becomes a problem, Zofran can be added to help control it
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Some of these will be mild, like flatulence, cramping, or constipation, whilst others can be more severe
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