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This physiological state, diabetic ketoacidosis (DKA), results from a reduced supply of glucose, due to lack of circulating insulin in the absence of therapeutic injection, and a concomitant increase in fatty acid oxidation due, in large part, to an unregulated increase in circulating glucagon
GSH levels rise in plasma and red blood cells, then decline due to relatively rapid metabolism
Pugh, P
Approval usually depends on provider documentation, lifestyle changes, and, sometimes, step therapy, which requires that lower-cost treatments or programs be tried first
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