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Are sulfur burps a sign that semaglutide is working for weight loss

They induce intracellular signalling that limits the recruitment of beta-arrestin-1, resulting in reduced GLP-1 receptor desensitisation and increased cyclic AMP production.4 Unlike oral SEMA, orforglipron does not require specific pre-administration conditions

PMID: 36792890

However, credible human clinical evidence for these compounds in liver disease is lacking, and they are not approved for any therapeutic use in this context