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The PRR family (nucleotide-binding oligomerization domain-like receptors [NLRs]) contains membrane-associated Toll-like receptors (TLRs), C-type lectin receptors (CLRs) like Dectin-1, and cytosolic nucleotide-binding and oligomerization domain (NOD)-like receptors (Salzman et al., 2007

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A 2026 study published in The Lancet found a similar pattern with tirzepatide in a similar cohort of postmenopausal women