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Efficacy and safety of lixisenatide once-daily versus placebo in patients with type 2 diabetes mellitus insufficiently controlled on sulfonylurea metformin (GetGoal-S.) [abstract 785]
Poor sleep increases ghrelin (hunger hormone) and decreases leptin (satiety hormone), making weight loss more difficult
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Therapeutic interventions are aimed at either increasing elimination of the parent drug or enhancing cytoprotective pathways to reduce the cytotoxic effects
Gut microbe-derived metabolite trimethylamine N-oxide induces cardiac hypertrophy and fibrosis
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